The Contracoagulantes And Primary Pulmonary Hypertension

Primary pulmonary hypertension, a rare and potentially fatal disease that increases blood pressure in the lungs and damages the heart valves, it can be treated through a variety of methods, including changes in lifestyle, medication, and lungs and heart transplants. Often the result of using diet drugs such as Fen-Phen. Unfortunately, this disease is not yet cured and has a poor prognosis.


Symptoms of primary pulmonary hypertension include fatigue, shortness of breath, dizziness, fainting, swelling in the ankles or legs, blue discoloration of the lips, and chest pain. Fortunately, some medications, such as contracoagulantes, can help control the symptoms of the disease and improve quality of life for those affected with HPP.

The contracoagulantes work in the body by preventing blood clotting. Medications can prevent new clots from forming or an existing clot bigger. The existing contracoagulantes do not dissolve clots. By reducing blood clotting, such drugs decreases tension in the heart of primary pulmonary hypertension, which makes it easier to pump blood through the pulmonary artery. Several studies showed that the rate increases patient survival when treatment with contracoagulantes occurs.

Two common example of contracoagulantes used today include heparin and warfarin. Heparin is a biological substance derived from pig intestines. It works by activating the contratrombina III, leaving thrombin blood clotting. Warfarin, the most commonly used in the United States contracoagulante, works by inhibiting vitamin K-dependent synthesis of active forms of calcium various coagulation factors. The dosage of these drugs is difficult because often interact with many commonly prescribed drugs. Even a diet high in vitamin K will change the effects of warfarin, making the drug less effective. Side effects such as warfarin contracoagulantes include bleeding, warfarin necrosis, osteoporosis and purple toe syndrome.

Addition of anti-clotting medication, other drugs can be used to relieve symptoms of PPH. Blockers, calcium channel blockers and vasodilators are sometimes used in the treatment of primary pulmonary hypertension. Blockers, calcium channel work to implement the vascular smooth muscle in the lungs to open, reducing pulmonary blood pressure. Vasodilators such as Flonan and Tracleer work by activating a reaction to endothelial cells, which reduces the stress and strain.

Primary pulmonary hypertension is a severe and complicated disease. Modern medications, such contracoagulantes can help relieve symptoms of the disease. Unfortunately, not available with the cure, medications can only help patients control negative side effects.

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