Allergic Asthma - What Have The Virus Came To Do With It?

Brief Statistics

1. Costs associated with asthma 1-2 of total health budgets on direct costs, indirect costs big for lost work time and reducing productivity.1
2.
The survey data shows that 95 of asthmatics have dust mite allergens (Dermatophagoides pteronyssinus) inside your mattress, at higher levels of WHO guidelines.1
3. The survey data shows that approximately 17 homes are contaminated with mold. This is important as there is strong evidence linking asthma exacerbations pollution indoor environment with moulds.1
4. Since most people spend 90 of their time indoors, exposure to major allergens is significant.1
5. Up to 35 of the population demonstrate reactivity tests allergens.1
6. population 5-10 show the clinical characteristics of one or more allergic disorders such as asthma, hay fever or eczema.1
7. The Health Survey for England (2002) reported rates of physician-diagnosed asthma in 0-15 20.5 years and 14.5 for all ages.1
8. The repeated surveys have shown that the incidence of asthma is constant in the increase.1
9. Epidemiological evidence suggests that certain viral infections can not only trigger asthma-related symptoms, but also contribute to allergic sensitization and the development of asthma.2
10. Behavior clinical and epidemiological observations strongly link with acute viral infection worsening asthma as many as 80 cases in children and 60 in adults.3
Introduction
Allergic asthma is a chronic inflammatory lung disease characterized by inflammation of the airways (resulting swelling in the airways), mucus hypersecretion and airway hyperresponsiveness in response to inhaled allergens such as pollen, dust mites, molds, spores fungi, etc, causing narrowing of the airways .4 In recent decades, there has been a dramatic increase in the prevalence of asthma and other allergic diseases in more developed economically and rapidly developing countries. As a result, they have become major public health problems and a huge burden on health care resources. Asthma is a serious and potentially fatal systemic allergic reactions, which adversely affect the quality of life of millions of adults and children.5
Role of viruses
There is substantial evidence that respiratory viral infections are associated with the development of allergic sensitization, asthma and other allergy related diseases. Several factors, including age, virus type, severity, location and time of infection, as well as interactions with the allergens and asma or contaminants that have been implicated in the development of allergic diseases associated with viral infections, especially asthma 2 Recent studies have shown that allergens and viruses can act together to exacerbate asthma. This indicates that domestic exposure to allergens acts in collaboration with the virus in sensitized patients (ie allergy sufferers), which increases the risk of hospital admission.1 Although its exact role in viral infections of the respiratory tract remains controversial, the influenza virus (INF), respiratory syncitial virus (RSV) and Rhinovirus (RV) have been implicated in causing allergic sensitization and the development of asthma.4 Traditionally, the RV has been considered as the most frequent cause respiratory symptoms in preschool children, while older children and adults, RV represents more than 50 virus-triggered exacerbations.2, 3 What is peculiar about RV is that, unlike many other viral infections, periodically re-infects children and adults. As is the case with exposure to allergens, age of first infection may play an important role in the subsequent response to new infection at an older asma This fact is especially important in preschoolers. Exposure to allergens and viruses can happen anywhere: at home, in offices, factories, schools, etc.
Current preventive measures to viral exacerbation of allergic asthma
Current preventive measures include
1. Vaccination: This usually occurs in early childhood and some evidence suggests that some vaccines may influence the development of allergy. However, clinical trials have not been performed to evaluate the immune modulating effect of vaccination on primary prevention of allergy. Nor is there a vaccine against virus as rhinovirus.5
2. contravirales Agents: Currently there are no specific active agent against human rhinovirus, which is the leading viral cause of asthma exacerbations triggered in adults and children. Several possible contravirales compounds are being evaluated, and some have reached clinical trials testing.3
3. In the absence of effective strategies to control viruses, reducing exposure to allergens is also a preventive measure, however, how this is possible? One
4. Air quality solutions such as air purifiers and air sterilisers, which are increasingly popular.

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